GENERAL SUMMARY/ OVERVIEW STATEMENT:

The laboratory of Dr. Haobo Li at MGH is seeking a full-time Research Technician I to perform:

(1) Basic molecular biology, (2) Cell culture methods, and (3) Small animal work.

The lab studies the pathophysiology of heart disease with a growing focus on crosstalk between heart and brain. Our investigations focus on fundamental cellular processes such as cell growth, survival and regeneration, as well as on the identification and validation of new therapeutic targets. Effects of genetic, pharmacological, and physiological (e.g., exercise) interventions are explored using high throughput profiling and screening techniques as well as mechanistic studies in mouse and cell culture models. Several promising therapeutic targets have come out of our work, including intracellular and intercellular signaling proteins and non-coding RNAs. The selected candidate will join a group of talented and motivated basic and clinician scientists whose work has direct translational applications.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

• Prepares basic solutions and performs base-level procedures as assigned (i.e. - pipetting, cell and tissue culture, etc.)
• Maintains laboratory notebook
• Understands and applies basic scientific techniques
• Conducts analysis of results and may begin interpretation of results
• Sets up and prepares routine experiments as directed
• Prepares lab reagents, chemicals, instruments and equipment
• May perform independent literature searches
• Assists with organizing materials for publication or presentation
• Maintains and orders supplies
• Rodent work (genotyping, pharmacological, and behavioral measurements etc.)
• Molecular biology/biochemical techniques (e.g, qPCR and Western blot, DNA subcloning, CRISPR-based genome editing, immunohistochemistry, histology, and enzyme assays, as well as data collection and analysis).

SKILLS/ABILITIES/COMPETENCIES REQUIRED:

• Ability to work independently and as a team member
• Good communication skills
• Computer literacy
• Ability to perform multiple tasks independently
• Highly motivated to learn about cardiac physiology and neuroscience
• Interested in applying powerful genetic, biochemical, animal models, and high throughput '-omic' strategies
• Eager to read primary literature related to the basic science of cardiac/ neurological health and disease

EDUCATION:

• Bachelor's degree required.
  

EXPERIENCE:

• New graduates with some lab experience (via course work, internships, etc.) or those without any prior research experience will be considered for the Research Technician I position outlined above.

WORKING CONDITIONS:

The candidate will be working in standard MGH research laboratory and with small animals (mice and rats) in MGH animal facility.

Massachusetts General Hospital is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.